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The approval of Mounjaro is an exciting step forward for people living with type 2 diabetes given the results seen in these clinical trials. Patrick Archdeacon, MD, associate director of the Division of Diabetes, Lipid Disorders and Obesity within the FDAs Center for Drug Evaluation and Research, also commented on the approval in an agency statement

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These findings confirm a previous study in which an acute injection of a higher semaglutide dose (0.1 mg/kg) decreases alcohol intake in male rats (Arans et al., 2023

This almost 100-fold difference in intrinsic clearance for both drugs, depending on the allelic variant considered, is of significance in the interpretation of clinical data